By Jan P. A. Baak M.D., Ph.D., Jan Oort M.D., Ph.D. (auth.)
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1980). The threshold approach to clinical decision making. N. Engl. J. Med. 302, 1109-1117. G. A. (1981). Nine-cell diagnostic decision matrix. Am. J. Clin. Pathol. 75, 769-772. I. G. (1981). Pathology and probabilities. A new approach to interpreting and reporting biopsies. N. Engl. I. Med. 305, 917-923. 40 Chapter 5 Structural Morphology J. A. 1 Introduction Normal and pathologically changed human organs, tissues and cells are very complicated structures. In diagnostic pathology one tends to look at special structural features, overlooking other details regarded as unimportant.
Obviously, there is a certain relationship between the number of objects in the learning set and the number of features allowed in the analysis. In general it is desirable that the ratio N IF of the number of objects ("patients") N and the number of features F should be greater than five. The results of the test set are usually 34 slightly worse than the results of the learning set. If the differences in classification results are too great, systematic differences between the learning set and test set should be suspected.
This means that the amount of dye is directly proportional to the chemical component it has to detect. Examples are the Feulgen (DNA}-naphthol yellow (protein) stain. Section quality was improved by using plastic-embedded material. But there was a totally different approach, too, called digital image (picture) processing. Fourthly, the DNA patterns measured were of some value, especially in selected cases, but the conventional object scanners were very slow. Two important lines therefore have to be discussed in direct connection with scanning photometry: flow-cyto(photo )metry and digital image processing.
A Manual of Morphometry in Diagnostic Pathology by Jan P. A. Baak M.D., Ph.D., Jan Oort M.D., Ph.D. (auth.)