By Rhonda Yantiss
Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix, a quantity within the Advances in Surgical Pathology sequence, gains chapters on present and forthcoming alterations within the box with an emphasis on useful concerns, fresh advancements, and rising concepts.
Created as a short evaluate for use in the course of pathologic review of melanoma specimens from the decrease gastrointestinal tract, this ebook includes the most recent information about rising endoscopic strategies that relief in tumor class and staging, mechanisms of pathogenesis, and scientific management.
It combines gross and microscopic photos and straight forward tables for speedy reference with a succinct, complete overview of matters vital to administration of sufferers with colorectal carcinoma. not just does it speak about the utilized difficulty of melanoma epidemiology and prevention, the ebook additionally covers pathological good points of melanoma precursors. Plus, an creation to destiny diagnostic and therapy modalities, corresponding to biomarker research, chemotherapeutic recommendations, unique molecular cures, and competitive multidisciplinary ways to sufferers with complicated degree disease.
- Emphasizes clinically and practically relevant information, including pathology reports and molecular test results
- Covers appropriate surgical anatomy, gross exam, and specimen coaching options to assist within the dealing with of surgical resection specimens
- Provides a simple wisdom of surgical pathology and molecular evaluate of colonic and appendiceal cancer
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Additional info for Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix
10,11 Hyperplastic polyps stain for colon-specific apomucin (MUC2) and gastric mucin (MUC5AC) and are reportedly negative for pyloric mucin (MUC6). 7,11 Many hyperplastic polyps have mutually exclusive KRAS and BRAF mutations, challenging the notion that they are nonneoplastic and lack malignant potential. 14 (c) 2015 Wolters Kluwer. All Rights Reserved. 36 Section II • Cancer Precursors: Colorectal Polyps and Chronic Colitis SESSILE SERRATED POLYPS Clinical and Endoscopic Features of Sessile Serrated Polyps Sessile serrated polyps are nondysplastic polyps that show a predilection for the abdominal colon and, unlike most hyperplastic polyps, are more common among women.
Thus, screening guidelines parallel those for conventional adenomas with overt dysplasia. 2A). 2B). 7,18 Distinction of sessile serrated polyp from hyperplastic polyp is subject to a high degree of interobserver variability, particularly when polyps are smaller than 1 cm in diameter and occur in the left colon. Diagnostic challenges stem from the fact that there are no “hard” criteria for a diagnosis of sessile serrated polyp.
Flat-elevated and depressed, subtypes of flat early colorectal cancers, should be distinguished by their pathological features. Int J Colorectal Dis 2000;15(5–6):275–281. 18. Imperiale TF, Wagner DR, Lin CY, et al. Results of screening colonoscopy among persons 40 to 49 years of age. S. ] 2002;346(23):1781–1785. (c) 2015 Wolters Kluwer. All Rights Reserved. Chapter 3 • Screening and Surveillance for Prevention of Colorectal Carcinoma 29 19. Konishi F, Morson BC. Pathology of colorectal adenomas: a colonoscopic survey.
Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix by Rhonda Yantiss