Download e-book for iPad: Amiloride-Sensitive Sodium Channels: Physiology and by Dale J. Benos (Eds.)

By Dale J. Benos (Eds.)

ISBN-10: 0080585183

ISBN-13: 9780080585185

ISBN-10: 0120890305

ISBN-13: 9780120890309

ISBN-10: 0121533476

ISBN-13: 9780121533472

Sodium reabsorbing epithelia play an important position in whole-body sodium homeostasis. a few examples of sodium regulating tissues comprise kidney, colon, lung, and sweat ducts. Sodium shipping throughout those membranes is a two-step procedure: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for shipping and are regulated via a number of diversified hormones. The sodium channels additionally play an important function in a few affliction states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful range offers the 1st in-depth alternate of rules referring to those sodium channels, their rules and involvement in general and pathophysiological events. Key gains * Summarizes present kingdom of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal rules of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * presents principles on sodium channels and affliction

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269,24379-24383. Snyder, P. , Price, M. , McDonald, F. , Adams, C. , Volk, K. , Zeiher, B. , Stokes, J. , and Welsh, M. J. (1995). Mechanism by which Liddle’s syndrome mutations increase activity of a human epithelial Nat channel. ) 83,969-978. Snyder, P. , Prince, L. , Rogers, J. , and Welsh, M. J. (1998). Electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits. J. Biol. Chem. 273, 681-684. Sorscher, E. , Accavitti, M. , Frizzell, R. , and Benos, D.

And Eaton, D. C. (1985). Single-channel recordings from amiloride-sensitive epithelial sodium channel. Am. J. Physiul. 249, C200-C207. Hansson, J. , and Lifton, R. P. (1995a). Hypertension caused by a truncated epithelial sodium channel gamma subunit: Genetic heterogeneity of Liddle syndrome. Nut. Genet. 11,76-82. Hansson, J. , Wilson, T. , Rossier, B. , and Lifton, R. P. (1995b). A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity.

262, 1061310618. Benos, D. , Fuller, C. , Shlyonsky, V. G . , Berdiev, B. , and Ismailov, I. I. (1997). Amiloride-sensitive Na' channels: Insights and outlooks. News Physiol. Sci. l2, 55-61. Berdiev, B. , Prat, A. , Cantiello, H. , Ausiello, D. , Fuller, C. , Benos, D. , and Ismailov, I. I. (1996). Regulation of epithelial sodium channels by short actin filaments. J . Biof. Chem. 271, 17704-17710. Bradford, A. , Berdiev, B. , Ismailov, I. , Fuller, C. , and Benos, D. J . (1997). Functional effects of mutations in the membrane spanning regions of the a-subunit of the amiloridesensitive Na' channel (ENaC).

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Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity by Dale J. Benos (Eds.)

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