By Dale J. Benos (Eds.)
Sodium reabsorbing epithelia play an important position in whole-body sodium homeostasis. a few examples of sodium regulating tissues comprise kidney, colon, lung, and sweat ducts. Sodium shipping throughout those membranes is a two-step procedure: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for shipping and are regulated via a number of diversified hormones. The sodium channels additionally play an important function in a few affliction states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful range offers the 1st in-depth alternate of rules referring to those sodium channels, their rules and involvement in general and pathophysiological events. Key gains * Summarizes present kingdom of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal rules of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * presents principles on sodium channels and affliction
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Extra resources for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity
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Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity by Dale J. Benos (Eds.)