Antibody-Drug Conjugates by Ingrid Sassoon, Véronique Blanc (auth.), Laurent Ducry PDF

By Ingrid Sassoon, Véronique Blanc (auth.), Laurent Ducry (eds.)

ISBN-10: 1627035400

ISBN-13: 9781627035408

Antibody-drug conjugates (ADCs) symbolize a promising healing process for melanoma sufferers through combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic efficiency of chemotherapeutic medications. In Antibody-Drug Conjugates, specialist researchers supply distinct protocols for lots of of the most important ADC recommendations beneficial for operating within the box. those chapters and methodologies are aimed toward the main initiatives essential to determine an appropriate aim, safely layout the mAb, the linker and the payload, in addition to to conjugate them in a reproducible and scalable model. Written within the hugely profitable Methods in Molecular Biology™ structure, those designated chapters comprise the type of sensible implementation suggestion that promises caliber results.

Authoritative and well timed, Antibody-Drug Conjugates goals to additional force ADC improvement and therefore aid towards bettering melanoma remedies of the future.

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Extra resources for Antibody-Drug Conjugates

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J Clin Oncol 28, Abstract 8525 85. Szol M, Hamid O, Hwu P et al (2009) Pharmacokinetics of CR011-vcMMAE, an antibody–drug conjugate, in a phase I study of patients with advanced melanoma. J Clin Oncol 27, Abstract 9063 86. Saleh M, Bendell J, Rose et al (2010) Correlation of GPNMB expression with outcome in breast cancer (BC) patients treated with the antibody–drug conjugate (ADC), CDX-011 (CR011-vcMMAE). J Clin Oncol 28, Abstract 1095 87. Hoashi T, Sato S, Yamaguchi Y et al (2010) Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein.

For an antibody to function as a successful component of an ADC, it needs to bind to the target antigen on the surface of tumor cells and then be internalized by the cell. Following internalization, the ADC has to be transported to the lysosome where subsequent intracellular processing of the ADC will release the biologically active drug to exert its cytotoxic effects on tumor cells. This chapter describes some of the techniques that are currently used to determine internalization and proper intracellular trafficking of antibodies in order to select an optimal antibody for ADC therapeutics.

Arteaga CL, Sliwkowski MX, Osborne CK et al (2012) Treatment of HER2-positive breast cancer: current status and future perspectives. Nat Rev Clin Oncol 9:16–32 48. Tsang RY, Finn RS (2012) Beyond trastuzumab: novel therapeutic strategies in HER2positive metastatic breast cancer. Br J Cancer 106:6–13 49. Phillips GD, Li G, Dugger DL et al (2008) Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody–cytotoxic drug conjugate. Cancer Res 68:9280–9290 50. Junttila TT, Li G, Parsons K et al (2011) Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer.

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Antibody-Drug Conjugates by Ingrid Sassoon, Véronique Blanc (auth.), Laurent Ducry (eds.)

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